Endah Ayu Tri Wulandari,* Rahmi Amtha,**

*Oral Medicine Division, Dentistry Department, Cipto Mangunkusumo General Hospital/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
**Oral Medicine Department, Faculty of Dentistry, Universitas Trisakti , Jakarta, Indonesia

Correspondence email to: rahmi.amtha@gmail.com


Allergic reaction affects up to 30% of the world’s population, with underlying pathophysiologyinvolving immunoregulatory dysfunctions and the most common oral symptom is ulceration.

Case Description
A 33-year-old male patient did doctor shopping of Oral Medicine Specialists in Jakarta with the fear of having oral cancer and was diagnosed of hypochondriasis by psychiatrist. The patient noticed a small irregular red macule on the palate that grew wider every day. There was no pain, bleeding or migration of lesion reported. Hematology profile showed an increased level of Immunoglobulin E (IgE). The red macule completely resolved after administration of Loratadine 10 mg once daily for a month. The patient was educated for routine oral check-up and psychiatry consultation.

Hypochondriasis may cause the immunoregulatory imbalance bymodulating Th2 cytokines system that responsible in IgE level and may produce the unspecific oral manifestationwhich gave positive response with antihistamine drug.

Keywords: illness-anxiety disorder, hypochondriasis, allergy, oral manifestation

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